Is it okay to take Claritin while pregnant? I can't find the original packaging and I only found out I was pregnant yesterday so I haven't picked out a doctor to ask yet and my allergies are killing me :(( Instructions for Taking Benadryl. Adults can take one to two 25-mg tablets of Benadryl every four to six hours. However, pregnant women should check in with their doctors regarding this dosage. Benadryl (generic name diphenhydramine) is usually considered safe to take while pregnant and is commonly used as a sedative and antihistamine for treating minor cold and flu symptoms such as runny/stuffy nose, congestion, sneezing, watery eyes, nausea as well as allergy symptoms like rashes, itching and hives [1]. Generally, you should not take any OTC medication while pregnant unless it is necessary. The following medications and home remedies have no known harmful effects during pregnancy when taken. Can I take Benadryl while I am pregnant? There has been little study done on the effects of Benadryl during pregnancy. Benadryl is considered a B class medication, which means that there is a reasonable amount of experience with a medication during pregnancy and no reason to believe that it would cause harm to the baby. I'm about 6.5 weeks pregnant, and I've been having trouble sleeping lately. Benadryl helps, but I was just curious if anyone knew if it was okay or not. Meilleure réponse: Benadryl is fine, but I would only take 25 mg. I will only take it at night if I'm too stuffed up to sleep. When I wake up to go to the bathroom, it makes me feel so sluggish that I can't imagine taking it during the day. Is it Okay to take Benadryl while Pregnant? The Food & Drug Administration has classified Benadryl as a category B drug for pregnancy, which means it is generally safe and doesn’t have any known major side effects for the baby. Although Benedryl is considered by most practitioners to be safe during pregnancy (and yes, I took it with mine), PLEASE!!! NEVER take medical advice from someone over the internet who doesn't know your medical history, especially when you are pregnant!!! References for breastfeeding information. Cerner Multum, Inc. Australian Product Information. O 0 Product Information. Benadryl (diphenhydramine). .